Research Articles
Master Protocols in Oncology: Revolutionizing Clinical Trial Design for Efficient Drug Development
This article provides a comprehensive overview of master protocol designs, a transformative approach for simultaneously evaluating multiple investigational drugs and/or cancer types within a single trial framework.
PDX vs. Organoid Models: A Comparative Analysis of Predictive Value in Oncology Drug Development
This article provides a comprehensive comparative analysis of Patient-Derived Xenograft (PDX) and Patient-Derived Organoid (PDO) models, two transformative technologies in preclinical oncology research.
Validating Cancer Stem Cell Biomarkers: From Bench to Bedside in Precision Oncology
The validation of reliable cancer stem cell (CSC) biomarkers is a critical frontier in oncology, holding the potential to revolutionize cancer diagnosis, prognosis, and therapeutic development.
Cross-Platform Validation of Multi-Gene Signature Assays: Strategies for Robust Clinical and Research Implementation
Multi-gene signature assays are transforming precision medicine by providing crucial prognostic and predictive insights in oncology and complex diseases.
IHC vs. NGS in Biomarker Testing: A Comprehensive Guide for Precision Oncology Research
This article provides a systematic comparison of Immunohistochemistry (IHC) and Next-Generation Sequencing (NGS) for biomarker testing in oncology research and drug development.
Prognostic vs Predictive Biomarkers: A Comprehensive Framework for Clinical Utility Assessment in Drug Development
This article provides a systematic guide for researchers, scientists, and drug development professionals on evaluating the clinical utility of prognostic and predictive biomarkers.
Beyond Accuracy: A Comprehensive Framework for Validating Machine Learning Models in Cancer Detection
This article provides a comprehensive guide for researchers and drug development professionals on the critical process of validating machine learning (ML) models for cancer detection.
Achieving Reproducibility in Organoid Research: A Comprehensive Guide to Standardized Culture Protocols
Organoid technology has revolutionized biomedical research by providing physiologically relevant in vitro models.
Genomic Predictors of Drug Sensitivity in Cancer: A Comparative Analysis of Models, Validation & Clinical Translation
This article provides a comprehensive comparative analysis of computational models for predicting anticancer drug sensitivity from genomic data.
Umbrella vs Basket Trials in Oncology: A Comprehensive Guide to Master Protocol Designs
This article provides a detailed comparison of umbrella and basket trial designs, two innovative master protocol frameworks revolutionizing oncology drug development.